TEGASEROD MALEATE EXERTS ANTI-TUMOR EFFECTS ON PROSTATE CANCER VIA REPRESSING SONIC HEDGEHOG SIGNALING PATHWAY

Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway

Abstract Prostate cancer (PCa) is a highly common type of malignancy and affects millions of men in the world since it is easy to CARB SMART BREAD recur or emerge therapy resistance.Therefore, it is urgent to find novel treatments for PCa patients.In the current study, we found that tegaserod maleate (TM), an FDA-approved agent, inhibited prolifera

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Bilateral and multilateral trade

The article shows that in the efforts to re-establish normal international relations on the basis of multilateral trade, confusion has often arisen concerning the distinction between those which are necessary effects or conditions, and those which are sufficient conditions, and that the disadvantages of bilateral trade have also been exaggerated.Th

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A Molecular Troika of Angiogenesis, Coagulopathy and Endothelial Dysfunction in the Pathology of Avascular Necrosis of Femoral Head: A Comprehensive Review

Avascular necrosis of the femoral head (ANFH) is a painful disorder characterized by the cessation of blood supply to the femoral head, leading to its death and subsequent joint collapse.Influenced by several risk factors, including corticosteroid use, excessive alcohol intake, hypercholesterolemia, smoking and some inflammatory disorders, along wi

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A Hybrid Personnel Scheduling Model for Staff Rostering Problems

The problem of staff scheduling in the airline industry is extensively investigated in operational research studies because efficient staff employment can drastically reduce the operational costs of airline companies.Considering the flight schedule of an airline company, staff scheduling is the process of assigning all necessary staff members in su

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